The France striker suffered the injury against Fulham on Saturday, and has told L`Equipe that he may be finished for the campaign.
"I`m on crutches, I don`t feel good," he said. "I don`t know whether I will have this ankle problem for days, weeks or months.
"But it`s going to be difficult for me to play again before the end of the season.
"It`s tiresome to get all these injuries. They all come along just when I`m starting to get a run going. It is hard. It sucks. But I`m trying to think positive."
Saha`s injury means manager David Moyes has just one recognised striker to call on in Jermaine Beckford, with Yakubu out on loan at Leicester.
Source: PA
Source: PA