Here, Press Association Sport looks at the five most prolific starters since the era began in 1992.
David James - 571 starts: A £1million signing from Watford, James made his Liverpool debut at the very start of the Premier League era against Brian Clough's Nottingham Forest
He was a familiar face for the next 18 seasons, taking in spells at Aston Villa, West Ham, Manchester City and Portsmouth and keeping 169 clean sheets along the way - a record only recently beaten by Petr Cech
First Premier League start, for Liverpool v Nottingham Forest, August 16 1992.
Gareth Barry - 571: A versatile performer whose Premier League career began in 1998 as a ball-playing defender at Aston Villa and has also taken in stints at left-back, left-midfield and, most frequently, midfield anchor
Played the vast majority of his football in 12 years at Villa before a big-money move to Manchester City and an ongoing Indian summer with Everton
First Premier League start, for Aston Villa v Sheffield Wednesday, May 2 1998.
Frank Lampard - 546: Lampard made his name at boyhood club West Ham and signed off from English football with Manchester City, but his is a name forever linked with Chelsea, where he became the club's record goalscorer
For a man whose eye for goal was so essential to his game, he fittingly netted in his final outing against Southampton in May 2015
First Premier League start, for West Ham v Arsenal, August 17 1996.
Ryan Giggs - 522: The definitive player of the Premier League era and the symbol of Manchester United's rise to dominance
Giggs had already broken into the United side in the old First Division and went on to claim 13 titles with the Red Devils, racking up a staggering 46,433 minutes of Premier League football
First Premier League start, v Sheffield United, August 15 1992.
Gary Speed - 521: When Speed lined up on the first day of the newly-formed Premier League, he did so as part of a Leeds side who had won the previous season's title
He never laid hands on the new trophy but carved out a fine career that saw him join Everton, Newcastle and Bolton
First Premier League start, v Wimbledon, August 15 1992.
Source : PA
Source: PA