The Frenchman, who scored four times in last week's defeat of Blackpool, strained a hamstring this week and is likely to be out for 10-14 days.
The news comes just a day after Everton confirmed midfielder Jack Rodwell could be sidelined for around four weeks with the groin injury sustained on England Under-21 duty.
Defender Phil Jagielka, who recently had a spell out with a thigh injury, is pushing for a start after two substitute appearances.
Source: PA
Source: PA