Seamus Coleman, Jack Rodwell (both ankle) and Tim Cahill (foot) are all doubtful but Victor Anichebe, injured on recent international duty, could be back in contention.
Playmaker Mikel Arteta (hamstring) remains on the sidelines while Louis Saha and Marouane Fellaini are long-term absentees.
Magaye Gueye and Apostolos Vellios could get further opportunities after making their Premier League debuts against Aston Villa last week.
Source: PA
Source: PA