Everton could be bolstered by the return from injury of Mikel Arteta and John Heitinga.
Arteta has missed the last five matches with a hamstring problem, while Heitinga was sidelined for last weekend's defeat at Manchester United.
Wigan
Injured: Pollitt (elbow)
Everton
Doubtful: Arteta, Baxter & Heitinga (all hamstring)
Injured: Barkley (broken leg), Fellaini & Saha (both ankle)
MATCH PREVIEW
Roberto Martinez maintains that his Wigan side "clicked as a team" 10 weeks ago, which raises concerns about their ability to avoid relegation given the fact they have only accrued two points from seven matches.
We've a real need for points at the moment and whether we get them or not will be decided by our performance and the help from our fans
Wigan manager Roberto Martinez
The Latics have not risen above the bottom four in 2011 and currently occupy 18th position. Martinez is glad to be playing at the DW Stadium after three straight away matches, but there has been little in the way of home comfort for his side this season.
Wigan's home record is the second worst in the division, and only as good as Everton's away form. The Latics also have a poor record in this fixture.
While they target survival, Everton's goal is to try to finish above city rivals Liverpool and finish sixth. It's a tough ask, with Manchester City and Chelsea still to come, but David Moyes's Everton rarely know when they are beaten. How Wigan need to replicate that fighting spirit in the season's run-in.
MATCH FACTS
Head-to-head
• Everton have won six and lost only one of their last eight meetings with Wigan.
• The Latics have beaten Everton once in five previous home matches - 1-0 in November 2008.
Wigan
• Wigan have only managed four wins and 19 points from 17 home games - only Blackpool have earned fewer points at home.
• They have only won one of their 18 matches against top-half opposition this season - at Tottenham back in August.
• Despite scoring five goals in their last two matches, Wigan share the dubious distinction of being the least potent side in the division. They and Birmingham average exactly a goal per game.
• The Latics have not kept a clean sheet for 17 matches and they have conceded four or more goals on 11 occasions since the start of last season.
Everton
• Everton's seven-match unbeaten streak was ended by Manchester United last weekend.
• The Toffees have opened the scoring in 16 league matches this season, losing only one (at Arsenal in February).
• Tim Howard will make his 300th appearance for an English club.
• Tony Hibbert is expected to start his 200th Premier League game for Everton.
LEADING GOALSCORERS
Wigan
Rodallega: 8 goals (8 league); N'Zogbia: 6 goals (5 league)
Everton
Saha: 10 goals (7 league); Cahill: 9 goals (9 league), Beckford: 9 goals (7 league)
MATCH OFFICIALS
Referee: Lee Mason
Assistant referees: Stuart Burt & Mick McDonough
Fourth official: Mike Jones
LAST LEAGUE MATCH LINE-UPS
Wigan (L2-4 v Sunderland, a): Al Habsi; Boyce (Stam 75), Alcaraz, G Caldwell, Gohouri, McCarthy (Moses 68), Diame, Watson, N'Zogbia (Di Santo 83), Cleverley, Rodallega. Subs not used: Kirkland, Thomas, Gomez, Sammon.
Everton (L0-1 v Man Utd, a): Howard; Hibbert, Jagielka, Distin, Baines, Coleman (Gueye 75), Neville, Rodwell, Bilyaletdinov (Cahill 46), Osman, Beckford (Anichebe 46). Subs not used: Mucha, Vellios, Mustafi, Duffy.
Source: BBC Sport
Source: BBC Sport